Drug interactions prevalence involving high-surveillance drugs
a crosssectional study
DOI:
https://doi.org/10.5935/1415-2762.20190074Keywords:
Patient Safety, Safety Management, Drug InteractionsAbstract
Objective: to estimate the prevalence of potential drug interactions (PDIs) related
to the high-surveillance drugs (HSD) used by a sample of patients admitted to an
intensive care unit (ICU). Methods: a cross-sectional, retrospective study with a
quantitative approach. Research was based on the analysis of patients prescriptions
admitted to the ICU over a one-year period (2014-2015) to identify potential drug
interactions related to recurrent HSDs. For each medical record, they were analyzed
from the first three to five prescriptions, depending on their availability and the period
of individual hospitalization. PDIs identification was made by consulting the Trissels
device from the Micromedex 2.0 database. Results: in the 244 drug prescriptions, 846
HSD-related PDIs and 112 different pairs of PDI involving the HSDs were identified.
The main HSDs in PDI were: regular insulin, midazolam, fentanyl and tramadol.
Of the 112 types of identified PDI, some were recurrent; namely: tramadol and
ondansetron, fentanyl and midazolam, midazolam and omeprazole, regular insulin
and hydrocortisone, as well as regular insulin and norepinephrine. HSD with PDIs
prevalence in this sample was 0.96 (96%). Conclusion: most patients were exposed
to PDI involving midazolam, fentanyl or regular insulin. Some vigilance should be established to avoid unnecessary interactions. Alternatively, when
the joint administration of certain interactants is indispensable skills
should be in place to manage this administration more appropriately
and with the lowest possible risk to the patient.
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